Translating knowledge of genetic disease mechanisms into gene therapies has been slow with limited clinical success. One major reason is that the transfer vectors, which are most often of viral origin ...

A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications. The approach, developed at Gladstone Institutes and UC ...

Viruses have been evolving for millions of years, improving their ability to transfer genetic material to the hosts they infect. When it comes to gene transfer, viruses are efficient and effective. So ...

A newly developed CRISPR system, using single-stranded DNA (ssDNA) HDR templates (HDRTs) incorporating Cas9 target sequences achieved two- to threefold better knock-in efficiency and yield relative to ...

In a recent study posted to the bioRxiv* preprint server, researchers proposed rotavirus (RV)-based vaccine vectors with the potential for developing polyvalent vaccines targeting multiple enteric ...